The researchers also tugged on the two ends of a DNA molecule after transcription to see what had happened to the nucleosome. They found that the nucleosome was frequently ejected from the DNA because the tension prevented the DNA from forming loops that would have allowed the nucleosome to skip over Pol II.
“We found that even a very small amount of tension in the DNA – 3 to 5 piconewtons – during transcription results in Pol II removing the nucleosome from DNA like a pair of wire strippers,” Hodges said. “It’s very likely that the DNA in our bodies is very taut at some places and loose in others, so we think it’s possible that the cell uses tension in the genome to alter the dynamics of nucleosomes in certain genes.”
See the full article from “UC Berkeley”
San Francisco Escorts: Manny Ramirez is old news »« San Francisco Adult Entertainment: Man found guilty of making threats against Obama
